m-Chloroperbenzoic acid → N-(4-methoxyphenyl)-2-oxiran-2-ylacetamide
반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:14])[CH2:11][CH:12]=[CH2:13])=[CH:5][CH:4]=1.ClC1C=CC=C(C(OO)=[O:23])C=1>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10](=[O:14])[CH2:11][CH:12]2[CH2:13][O:23]2)=[CH:5][CH:4]=1참가 물질
4
실험 절차
The solution of N-(4-methoxyphenyl)but-3-enamide (9) from the previous reaction was treated with m-chloroperbenzoic acid (2 eq.) and stirred at room temperature for 18 hours. The reaction mixture was diluted with dichloromethane, and washed with 1N sodium hydroxide. The organic phase was separated, dried over magnesium sulfate, filtered, and the filtrate evaporated under reduced pressure to give crude N-(4-methoxyphenyl)-2-oxiran-2-ylacetamide, a compound of formula (10).
후처리
- washwashed with 1N sodium hydroxide
- customThe organic phase was separated
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customthe filtrate evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-d46fb5af2e40471295de51925e8c9db5
- 출처 데이터셋
- uspto-grants-2007_04
- 특허 번호
- US07205303B2
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