Sodium Bicarbonate → Ethyl [2-(carbamoylamino)-1,3-thiazol-4-yl]acetate

HRID 127116노트

반응식

HRID 127116 반응식
ClC(Cl)(Cl)[NH:3][C:4](=[O:17])[NH:5][C:6]1[S:7][CH:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:10]=1.C(=O)(O)[O-].[Na+]>CO.O>[NH:5]([C:6]1[S:7][CH:8]=[C:9]([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:10]=1)[C:4]([NH2:3])=[O:17]

참가 물질

5

반응물 2

HCID 516892Sodium BicarbonateHCID 20288647HCID 20288647, 화합물

생성물 1

HCID 20288653Ethyl [2-(carbamoylamino)-1,3-thiazol-4-yl]acetate수율 82.5%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of ethyl 2-(3-trichloromethylureido)thiazol-4-ylacetate (6.32 g.) in a mixture of methanol (400 ml.) and water (150 ml.) was adjusted to pH 7 to 7.6 with sodium bicarbonate aqueous solution with stirring at room temperature, and then the solution was stirred for 70 minutes at the same temperature. The methanol was distilled off from the reaction mixture under reduced pressure, and the precipitates were collected by filtration, washed with water and then dried to give colorless crystals of ethyl 2-ureidothiazol-4-ylacetate (3.45 g.), mp 173° to 174° C.

후처리

  1. stirringthe solution was stirred for 70 minutes at the same temperature
  2. distillationThe methanol was distilled off from the reaction mixture under reduced pressure
  3. filtrationthe precipitates were collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-cfb46f823d0c4d6b831ccefdc84ea38d
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04254260

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