Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 5-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | 5-(2-Fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine | HCID 58994155 | — |
| 생성물 | 5-(2-fluoro-3-pyridinyl)-2,4(1H,3H)-pyrimidinedione hydrochloride | HCID 68694502 | — |
반응 단계
A solution of 5-(2-fluoro-3-pyridinyl)-2,4-bis(methyloxy)pyrimidine (Prep87, 2.8 g, 11.90 mmol) in HCl 4M in 1,4dioxane (42 mL, 168 mmol) was heated at 90° C. for 1 h. A white precipitate crashed out of the solution. Volatiles were evaporated under reduced pressure to give title compound, pale yellow solid (2.75 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07727988B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-7dfa12c1ad044b53834cd890affd01db |
| 출처 메모 | uspto-grants-2010_06 |