Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2-chloronicotinate → Methyl 2-[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2-chloronicotinate | HCID 819931 | — |
| 반응물 | 1-(4-Aminophenyl)-2-methylpropan-1-one | HCID 5151044 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 2-Methoxyethanol | HCID 8019 | — |
| 생성물 | Methyl 2-[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate | HCID 22603050 | 118.9% |
반응 단계
A mixture of 1-(4-aminophenyl)-2-methyl-1-propanone (0.0637 mol) and methyl 2-chloro-3-pyridinecarboxylate (0.0637 mol) in 2-methoxyethanol (200 ml) was stirred and refluxed for 90 hours. The mixture was taken up in water and EtOAc and extracted with EtOAc. The organic layer was separated, dried, filtered and the solvent was evaporated, yielding 22.6 g of methyl 2-[[4-(2-methyl-1-oxopropyl)phenyl]amino]-3-pyridinecarboxylate (interm. 20).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07205312B2 |
| 출처 데이터셋 | uspto-grants-2007_04 |
| ORD ID | ord-71732c7497d140babc61853ec49c0d5a |
| 출처 메모 | uspto-grants-2007_04 |