Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 9-Deoxo-9a-aza-9a-homoerythromycin A
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Nitroxyl | HCID 945 | — |
| 반응물 | Azithromycin | HCID 447043 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Sodium borohydride | HCID 4311764 | — |
| 생성물 | 9-Deoxo-9a-aza-9a-homoerythromycin A | HCID 9810601 | — |
반응 단계
In accordance with one aspect of the present invention, there is provided a method of preparing azithromycin of formula (I) comprising the steps of: (a) reducing 6,9-imino ether of formula (III) dissolved in methanol with 5 to 7 mole equivalents of NaBH4 at −20 to −10° C., treating the reaction mixture with an acidic aqueous acetone solution of citric acid, and adjusting the solution pH to 10.5 to 12.0 to obtain a crystalline hydrate of 9-deoxo-9a-aza-9a-homoerythromycin A of formula (II); and
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07205395B2 |
| 출처 데이터셋 | uspto-grants-2007_04 |
| ORD ID | ord-9ed99655c21a44dbbb87fc15876b39f3 |
| 출처 메모 | uspto-grants-2007_04 |