Ethyl bromoacetate → HCID 11287642, 화합물

HRID 1271602노트

반응식

HRID 1271602 반응식
[OH:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[O:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>CC(C)=O>[CH3:10][O:9][C:7]([C:5]1[O:4][N:3]=[C:2]([O:1][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:6]=1)=[O:8]

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 178498603HCID 178498603, 화합물

생성물 1

HCID 11287642HCID 11287642, 화합물수율 81%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of methyl 3-hydroxy-isoxazole-5-carboxylate (7.14 mmol) in acetone (30 mL), was added potassium carbonate (1.2 g, 8.6 mmol) and ethyl bromoacetate (8.6 mmol). The reaction mixture was heated at reflux for 2 h, monitoring by TLC. At completion, acetone was removed in vacuo and the residue partitioned between water and ethyl acetate (50 mL). The organic layer was dried (MgSO4), filtered, and evaporated to afford the desired intermediate.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 2 h
  3. customAt completion, acetone was removed in vacuo
  4. customthe residue partitioned between water and ethyl acetate (50 mL)
  5. dry with materialThe organic layer was dried (MgSO4)
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-d4789fc4c7f14e95b044832e17a3af69
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205403B2

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