Pyridine → HCID 22936218, 화합물

HRID 1271615노트

반응식

HRID 1271615 반응식
N1C=CC=CC=1.[C:7](Cl)(=[O:15])[O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[C:17]1([N:23]2[CH2:28][CH2:27][CH:26]([NH2:29])[CH2:25][CH2:24]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(=O)(O)[O-].[Na+]>O1CCCC1>[C:17]1([N:23]2[CH2:24][CH2:25][CH:26]([NH:29][C:7](=[O:15])[O:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH2:27][CH2:28]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

6

반응물 4

HCID 1049PyridineHCID 15891Phenyl chloroformateHCID 516892Sodium BicarbonateHCID 211933471-Phenylpiperidin-4-amine

생성물 1

HCID 22936218HCID 22936218, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Pyridine (24 μL) and phenyl chlorocarbonate (32 μL) were added to a solution of 1-phenyl-4-piperidylamine (35 mg) in tetrahydrofuran (1 mL), and the mixture was stirred at room temperature for 12 hours. The reaction mixture was poured into saturated aqueous sodium bicarbonate, and extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography on silica gel (ethyl acetate/chloroform=1/1) to give the title compound (37 mg).

후처리

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated
  4. customThe residue was purified by column chromatography on silica gel (ethyl acetate/chloroform=1/1)

출처 및 근거

ORD 기록
ord-4b775339ee004b55b3e5c56ed380e9fb
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205417B2

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