Potassium Carbonate → HCID 12138357, 화합물

HRID 1271673노트

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HRID 1271673 반응식
[SH:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([SH:12])[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:13]([C:17]1[CH:18]=[C:19]([CH:22]=[C:23]([C:25]([CH3:28])([CH3:27])[CH3:26])[CH:24]=1)[CH2:20]Br)([CH3:16])([CH3:15])[CH3:14].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:13]([C:17]1[CH:18]=[C:19]([CH:22]=[C:23]([C:25]([CH3:28])([CH3:27])[CH3:26])[CH:24]=1)[CH2:20][S:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([S:12][CH2:20][C:19]2[CH:18]=[C:17]([C:13]([CH3:15])([CH3:14])[CH3:16])[CH:24]=[C:23]([C:25]([CH3:28])([CH3:27])[CH3:26])[CH:22]=2)[CH:11]=1)[C:5]([O:7][CH3:8])=[O:6])([CH3:16])([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 44475071-(Bromomethyl)-3,5-di-tert-butylbenzeneHCID 12138349HCID 12138349, 화합물

생성물 1

HCID 12138357HCID 12138357, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Methyl 3,5-dimercaptobenzoate (20.0 g, 100.0 mmol), 3,5-di-tertiarybutylbenzyl bromide (molecular weight 283.25, 57.0 g, 201.2 mmol) and potassium carbonate (molecular weight 138.21, 28.0 g, 202.6 mmol) were dissolved, in 350 ml of acetone and the mixture was heated under reflux for 12 hours. The acetone and salts were removed, and the residue was purified by means of chromatography with dichloromethane as the developing solvent, giving methyl 3,5-bis(3,5di-tertiary-butylbenzylthio)benzoate as needles.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 12 hours
  3. customThe acetone and salts were removed
  4. customthe residue was purified by means of chromatography with dichloromethane as the developing solvent

출처 및 근거

ORD 기록
ord-2ee642cbb1a84df8b5fc07f4f7ace5cb
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205428B2

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