Potassium Carbonate → Methyl 3-[(4-formyl-2-nitrophenyl)sulfanyl]propanoate

HRID 1271694

반응식

HRID 1271694 반응식
Cl[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][C:3]=1[N+:10]([O-:12])=[O:11].[SH:13][CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH:6]([C:5]1[CH:8]=[CH:9][C:2]([S:13][CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])=[C:3]([N+:10]([O-:12])=[O:11])[CH:4]=1)=[O:7]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 18050Methyl 3-mercaptopropionateHCID 855054-Chloro-3-nitrobenzaldehyde

생성물 1

HCID 18454516Methyl 3-[(4-formyl-2-nitrophenyl)sulfanyl]propanoate수율 97%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-chloro-3-nitrobenzaldehyde (2.60 g, 0.014 mole) and methyl 3-mercaptopropionate (1.92 g, 0.016 mole) in DMF (10 mL) was added anhydrous K2CO3 (2.07 g, 0.016 mole). After stirring at ambient temperature for 16 hr, the reaction was quenched with ice water. The precipitated product was collected by suction filtration, washed well with water, and dried in vacuo to give a bright yellow solid (3.65 g, 97%).

후처리

  1. customthe reaction was quenched with ice water
  2. filtrationThe precipitated product was collected by suction filtration
  3. washwashed well with water
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-3d649518d24644d2819806010402f9d3
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205408B2

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