5-(6-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione → 3-[5-(6-Chloro-pyridin-3-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-propionaldehyde

HRID 12717노트

반응식

HRID 12717 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:9](=[O:22])[NH:10][C:11](=[O:21])[N:12]([CH2:14][CH2:15][CH:16](OC)[O:17]C)[CH:13]=2)=[CH:4][CH:3]=1>C1COCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[C:9](=[O:22])[NH:10][C:11](=[O:21])[N:12]([CH2:14][CH2:15][CH:16]=[O:17])[CH:13]=2)=[CH:4][CH:3]=1

참가 물질

3

반응물 1

HCID 589941995-(6-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione

생성물 1

HCID 589942093-[5-(6-Chloro-pyridin-3-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-propionaldehyde

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
40 °C

실험 절차

5-(6-Chloro-pyridin-3-yl)-1-(3,3-dimethoxy-propyl)-1H-pyrimidine-2,4-dione (Prep92, 267 mg, 0.82 mmol) was dissolved in THF (10 ml) and then 1N HClaq (0.82 ml) was added. The solution was stirred at 40° C. for 1.5 hours. TEA (116 μl, 0.83 mmol) was added and the solvent was removed in vacuum at room temperature. Residue was freeze dried to give a white powder that was used in the next step without further purification (quantitative yield).

후처리

  1. addition1N HClaq (0.82 ml) was added
  2. customthe solvent was removed in vacuum at room temperature
  3. customdried
  4. customto give a white powder that
  5. customwas used in the next step without further purification (quantitative yield)

출처 및 근거

ORD 기록
ord-06092e2182fb448f8c85e017bcd16aec
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727988B2

반응 노트

불러오는 중…