Thionyl Chloride → 4-(2-oxopyridin-1(2H)-yl)benzoyl chloride
반응식
[O:1]=[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]1[C:8]1[CH:16]=[CH:15][C:11]([C:12](O)=[O:13])=[CH:10][CH:9]=1.O=S(Cl)[Cl:19]>ClCCCl>[O:1]=[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([Cl:19])=[O:13])=[CH:10][CH:9]=1참가 물질
4
실험 절차
4-(2-oxopyridin-1(2H)-yl)benzoic acid (1 g, 4.6 mmol) was ]mixed with 10 mL of 1,2-dichloroethane. To this suspension was added SOCl2 (6 mL), and the mixture was refluxed for 1.5 h. The mixture was reduced in vacuo. The remaining traces of SOCl2 were removed by adding 1,2-dichloroethane (2×5 mL) and evaporating to dryness to yield 4-(2-oxopyridin-1(2H)-yl)benzoyl chloride as a white solid.
후처리
- temperaturethe mixture was refluxed for 1.5 h
- customThe remaining traces of SOCl2 were removed
- additionby adding 1,2-dichloroethane (2×5 mL)
- customevaporating to dryness
출처 및 근거
- ORD 기록
- ord-9a3b8b62b1204cdc908ca53f8022c1a0
- 출처 데이터셋
- uspto-grants-2007_04
- 특허 번호
- US07205318B2
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