tert-Butyl carbamate → HCID 10048021, 화합물

반응식

C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]([C:33](=[O:36])[CH:34]=[CH2:35])[CH:11]([C:14]1[N:23]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22](=[O:31])[C:21]2[C:16](=[CH:17][C:18]([Cl:32])=[CH:19][CH:20]=2)[N:15]=1)[CH2:12][CH3:13])(C)(C)C.C(OC(=O)N)(C)(C)C>>[CH2:24]([N:23]1[C:22](=[O:31])[C:21]2[C:16](=[CH:17][C:18]([Cl:32])=[CH:19][CH:20]=2)[N:15]=[C:14]1[CH:11]([N:10]1[C:33](=[O:36])[CH2:34][CH2:35][NH:7][CH2:8][CH2:9]1)[CH2:12][CH3:13])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

참가 물질

반응물 2

HCID 77922tert-Butyl carbamate

HCID 69475326HCID 69475326, 화합물

생성물 1

HCID 10048021HCID 10048021, 화합물

실험 절차

Preparation of (2-{acryloyl-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propyl]-amino}-ethyl)-carbamic acid tert-butyl ester: Following the procedure of Example of 1c, 2-[1-(3-benzyl-7-chloro-4-oxo-3,4-dihydro-quinazolin-2-yl)-propylamino]-ethyl}-carbamic acid tert-butyl ester (940 mg, 2 mmol) was converted to the title compound as a white solid: MS (ES) m/e 525.4 (M+H)+.

출처 및 근거

ORD 기록: ord-9870fefa3f554e7e8e8a056330b0cc75
출처 데이터셋: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07208487B2

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