Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Methoxypyridine-3-carbaldehyde → Ethyl 3-(6-methoxy-3-pyridyl)acrylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Methoxypyridine-3-carbaldehyde | HCID 3364576 | — |
| 반응물 | Propanedioic acid, monoethyl ester | HCID 3595298 | — |
| 촉매 | Piperidine | HCID 8082 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Ethyl 3-(6-methoxy-3-pyridyl)acrylate | HCID 53930754 | 79.2% |
반응 단계
A mixture of 6-methoxypyridine-3-carboxaldehyde (2.34 g), monoethyl malonate (4.51 g), pyridine (12 ml) and piperidine (6 drops) was heated under reflux for 5 hours and was evaporated to an oil. This oil was partitioned between ether and dilute aqueous ammonia. The ether layer was washed with water and evaporated to an oil which crystallised on standing to give ethyl 3-(6-methoxy-3-pyridyl)acrylate (2.8 g, 79%), m.p. 49-52°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04255428 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-0e168bd7f1a34e58b18e711c954c5def |
| 출처 메모 | uspto-grants-1981_03 |