Bromine → 2-Butanone, 1-bromo-4-chloro-3,3-dimethyl-

HRID 127235

반응식

HRID 127235 반응식
[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4](=[O:6])[CH3:5].[Br:9]Br>CCOCC>[Br:9][CH2:5][C:4](=[O:6])[C:3]([CH3:8])([CH3:7])[CH2:2][Cl:1]

참가 물질

4

반응물 2

HCID 24408Bromine2회HCID 110624414-Chloro-3,3-dimethylbutan-2-one

생성물 1

HCID 104207672-Butanone, 1-bromo-4-chloro-3,3-dimethyl-수율 80%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

134.5 g (1 mol) of 1-chloro-2,2-dimethyl-butan-3-one were dissolved in 500 ml of ether. 51 ml (1 mol) of bromine were added dropwise at room temperature, with slight cooling, at a rate such that the bromine was steadily consumed. The solution was then stirred into 1,000 ml of ice-water and the organic phase was separated off, rinsed with 250 ml of water, dried over sodium sulphate and distilled. 169 g (80% of theory) of 1-bromo-4-chloro-3,3-dimethyl-butan-2-one of boiling point 95°-106° C./13 mm Hg were obtained.

후처리

  1. customwas steadily consumed
  2. customthe organic phase was separated off
  3. washrinsed with 250 ml of water
  4. dry with materialdried over sodium sulphate
  5. distillationdistilled

출처 및 근거

ORD 기록
ord-26c0cb7ed0254c2fa331b82a740c8c02
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255434

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