Trifluoroacetic acid → (1E)-2-(4-Chlorophenyl)ethenesulfonamide

HRID 1272355노트

반응식

HRID 1272355 반응식
CC([NH:9][S:10](/[CH:13]=[CH:14]/[C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=1)(=[O:12])=[O:11])(C)CC(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[Cl:21][C:18]1[CH:17]=[CH:16][C:15](/[CH:14]=[CH:13]/[S:10]([NH2:9])(=[O:11])=[O:12])=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 17748075(E)-2-(4-chloro-phenyl)-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide

생성물 1

HCID 6212331(1E)-2-(4-Chlorophenyl)ethenesulfonamide수율 89.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To (E)-2-(4-chloro-phenyl)-ethenesulfonic acid (1,1,3,3-tetramethyl-butyl)-amide (5.0 g, 15.2 mmol) in dichloromethane (10 ml) was added trifluoroacetic acid (10 ml) and the mixture was stirred for 15 min. The mixture was concentrated in vacuo to afford a solid. The solid was washed with dichloromethane (5 ml) and heptane (150 ml). The resultant solid was collected by suction filtration. The solid was dried under vacuum at room temperature to afford (E)-2-(4-chloro-phenyl)-ethenesulfonic acid amide (2.95 g, 89%).

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. customto afford a solid
  3. washThe solid was washed with dichloromethane (5 ml) and heptane (150 ml)
  4. filtrationThe resultant solid was collected by suction filtration
  5. customThe solid was dried under vacuum at room temperature

출처 및 근거

ORD 기록
ord-f0e02833935c49e3bb4fd045b332985c
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208526B2

반응 노트

불러오는 중…