4-Methylbenzyl chloride → 1-(4-Methylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine

반응식

[OH:1][CH:2]([CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[CH3:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33]Cl)=[CH:31][CH:30]=1>>[CH3:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][N:7]2[CH2:8][CH2:9][N:4]([CH2:3][CH:2]([OH:1])[CH2:10][O:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:5][CH2:6]2)=[CH:31][CH:30]=1

참가 물질

반응물 2

HCID 77224-Methylbenzyl chloride

HCID 130377901-(2-Hydroxy-3-n-hexadecyloxypropyl)-piperazine

생성물 1

HCID 130377951-(4-Methylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine

실험 절차

Following the procedure of Example 5, 1-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine was reacted with 4-methylbenzyl chloride to form 1-(4-methylbenzyl)-4-(2-hydroxy-3-n-hexadecyloxypropyl)-piperazine, mp 238°-239° C.

출처 및 근거

ORD 기록: ord-ec00e716bff843f9bfa99578beac3d4b
출처 데이터셋: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04255426

반응 노트

불러오는 중…