참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dopamine | HCID 681 | — |
| 반응물 | Bicarbonate Ion | HCID 769 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 6-(Bromomethyl)-2-imino-2,3-dihydropteridin-4-amine--hydrogen bromide (1/1) | HCID 12503242 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 6-{[2-(3,4-Dihydroxy-phenyl)ethylamino]-methyl}-2,4-pteridinediamine | HCID 18455725 | 22.6% |
반응 단계
To a solution of 6-bromomethyl-2,4-pteridinediamine hydrobromide (67.3 mg, 0.2003 mmol) in anhydrous N,N dimethylacetamide was added 2-(3,4-dihydroxyphenyl) ethylamine (43.6 mg, 0.23 mmol). Under positive pressure of Argon, iPr2EtN (32.63 ul) was added. The reaction mixture was stirred at 50° C. for 4 hrs and then at Room temperature overnight. The crude product was poured into saturated bicarbonate solution. The resulted precipitate was collected and purified by preparative HPLC. 14.8 mg product was obtained. Yield: 22.6%; 1H NMR (500 MHz, DMSO-d6): δ 2.69242 (b, 4H), 4.03353 (s, 2H), 6.37542–6.39065 (d, J=7.615 Hz, 1H), 6.4851(s, 1H), 6.56632–6.58226 (d, J=7.97 Hz, 1H), 8.80972 (s, 1H); ESI-MS: m/z 328 (M++1)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07208493B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_04 |
|---|
| ORD ID | ord-09e79be0cd044caa97d569d8e6d6e144 |
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| 출처 메모 | uspto-grants-2007_04 |
|---|
