Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 8-Carbobenzyloxy-1-oxa-3,8-diazaspiro[4.5]decan-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Benzyl chloroformate | HCID 10387 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1-Oxa-3,8-diazaspiro(4.5)decan 2-one | HCID 12954114 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 8-Carbobenzyloxy-1-oxa-3,8-diazaspiro[4.5]decan-2-one | HCID 13016595 | 81.5% |
반응 단계
To a mixture of 9.5 g 1-oxa-3,8-diazaspiro[4.5]decan-2-one and 75 ml water, at 0°, is added 6.3 g sodium bicarbonate and 10.9 g benzyl chloroformate. The mixture is stirred 18 hours at 0°, acidified with 10 N hydrochloric acid and stirred four hours at room temperature. The mixture is extracted with three 50 ml portions of dichloromethane. Removal of solvent affords 14.4 g 8-carbobenzyloxy-1-oxa-3,8-diazaspiro[4.5]decan-2-one, mp 126°-128°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04255432 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-33202028d3524476be3805df397f91a2 |
| 출처 메모 | uspto-grants-1981_03 |