Water → ethyl 3-(4-fluorophenyl)-1H-indazole-5-carboxylate

HRID 1272755노트

반응식

HRID 1272755 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([C:13](Cl)=[O:14])=[CH:10][CH:11]=2)[C:6]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[N:5]1)(=O)C.N1[CH:28]=[CH:27]C=CC=1.[OH-:29].[NH4+].O>C(O)C>[F:22][C:19]1[CH:20]=[CH:21][C:16]([C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[C:9]([C:13]([O:29][CH2:27][CH3:28])=[O:14])[CH:8]=3)[NH:4][N:5]=2)=[CH:17][CH:18]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 1049PyridineHCID 14923Ammonium HydroxideHCID 224802271-acetyl-3-(4-fluorophenyl)-1H-indazole-5-carbonyl chloride

생성물 1

HCID 22479944ethyl 3-(4-fluorophenyl)-1H-indazole-5-carboxylate수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 1-acetyl-3-(4-fluorophenyl)-1H-indazole-5-carbonyl chloride (100 mg, 0.33 mmol) in ethanol (40 mL) was added pyridine (0.5 mL). The reaction was stirred overnight at room temperature when saturated ammonium hydroxide (1 mL) was added. The reaction was stirred overnight when water (150 mL) was added and the solution filtered. The solid was dried to recover the product (100 mg, 100% yield). 1H NMR (DMSO-d6) δ 13.6 (s, 1H), 8.62 (s, 1H), 8.03–7.9 (m, 3H), 7.70 (d, 1H), 7.61 (d, 1H), 7.42 (t, 2H); ES-MS (m/z) 285 [M+1]+.

후처리

  1. additionwas added
  2. additionwas added
  3. filtrationthe solution filtered
  4. customThe solid was dried

출처 및 근거

ORD 기록
ord-99838b70129941ccae365370ccbc5100
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208513B2

반응 노트

불러오는 중…