4-Aminopyridine → 3-(4-Pyridyl)-3-azaspiro[5,5]undecan-2,4-dione

HRID 127278노트

반응식

HRID 127278 반응식
[CH2:1]1[CH2:6][CH2:5][CH2:4][CH2:3][C:2]21[CH2:12][C:11](=[O:13])[O:10][C:8](=O)[CH2:7]2.[NH2:14][C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1.C1(C)C(C)=CC=CC=1>O>[N:18]1[CH:19]=[CH:20][C:15]([N:14]2[C:8](=[O:10])[CH2:7][C:2]3([CH2:1][CH2:6][CH2:5][CH2:4][CH2:3]3)[CH2:12][C:11]2=[O:13])=[CH:16][CH:17]=1

참가 물질

5

반응물 3

HCID 17274-AminopyridineHCID 7237O-XyleneHCID 27342891,1-Cyclohexanediacetic Anhydride

생성물 1

HCID 128225403-(4-Pyridyl)-3-azaspiro[5,5]undecan-2,4-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The starting material is prepared as follows: The mixture of 25 g of 2,2-cyclohexane diacetic anhydride, 12.92 g of 4-aminopyridine, and 400 ml of xylene is refluxed for 25 hours using a water separator. The hot, supernatant xylene solution is decanted from an oil precipitate (which is discarded), cooled, filtered and the residue recrystallized from ethanol, to yield the 3-(4-pyridyl)-3-azaspiro[5,5]undecan-2,4-dione melting at 213°-215°.

후처리

  1. customThe starting material is prepared
  2. temperatureis refluxed for 25 hours
  3. customThe hot, supernatant xylene solution is decanted from an oil precipitate (which is discarded)
  4. temperaturecooled
  5. filtrationfiltered
  6. customthe residue recrystallized from ethanol

출처 및 근거

ORD 기록
ord-9b3b763cada94dab80b9d46af27a0b77
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255429

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