4-Aminopyridine → 3-Methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione

HRID 127285

반응식

HRID 127285 반응식
[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])O[C:3]1=[O:4].[NH2:9][C:10]1[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=1.C1(C)C(C)=CC=CC=1>O>[CH3:1][CH:2]1[CH2:7][C:6](=[O:8])[N:9]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[C:3]1=[O:4]

참가 물질

5

반응물 3

HCID 17274-AminopyridineHCID 7237O-XyleneHCID 20051Methylsuccinic anhydride

생성물 1

HCID 128225463-Methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The starting material is prepared as follows: The mixture of 28.5 g of 2-methylsuccinic anhydride, 23.5 g of 4-aminopyridine and 350 ml of xylene is refluxed on a water separator while stirring for 3.5 hours. The hot solution is decanted from some gummy residue, cooled, filtered, the residue suspended in 100 ml of boiling isopropanol and filtered off again, to yield the 3-methyl-1-(4-pyridyl)-pyrrolidin-2,5-dione melting at 119°-120°.

후처리

  1. customThe starting material is prepared
  2. customThe hot solution is decanted from some gummy residue
  3. temperaturecooled
  4. filtrationfiltered
  5. filtrationfiltered off again

출처 및 근거

ORD 기록
ord-934277f0ce874393a387b4c7de63e85d
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255429

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