Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroacetic Acid → S-carboxymethyl-N-(2-carboxymethylthio-2-methylpropanoyl)-L-cysteine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroacetic Acid | HCID 300 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Iodide | HCID 4875 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Bucillamine | HCID 656604 | — |
| 용매 | Potassium Carbonate | HCID 11430 | — |
| 생성물 | S-carboxymethyl-N-(2-carboxymethylthio-2-methylpropanoyl)-L-cysteine | HCID 12876168 | 194.5% |
반응 단계
N-(2-Mercapto-2-methylpropanoyl)-L-cysteine (11.2 g, 0.05 mol) is dissolved in 1 M potassium carbonate and monochloroacetic acid (11.3 g, 0.12 mol) and potassium iodide (1.0 g) are added. The mixture is stirred overnight at room temperature under a nitrogen atmosphere and acidified with 6 N hydrochloric acid. Sodium chloride is added and the mixture is extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride solution, dried and concentrated to dryness to yield 16.5 g (97.2%) of S-carboxymethyl-N-(2-carboxymethylthio-2-methylpropanoyl)-L-cysteine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04255446 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-44272a91e41947378530daad8def6fc9 |
| 출처 메모 | uspto-grants-1981_03 |