Hydrazine → N-amino-2-piperidylacetamide

HRID 1272975노트

반응식

HRID 1272975 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][C:8]([O:10]C)=O.[NH2:12][NH2:13]>C(O)C>[NH2:12][NH:13][C:8](=[O:10])[CH2:7][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][NH:1]1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 5214606Methyl piperidin-2-ylacetate

생성물 1

HCID 12587996N-amino-2-piperidylacetamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of methyl 2-piperidylacetate (1.082 mL, 5.84 mmol) in 1 mL of anhydrous ethanol was added anhydrous hydrazine (0.283 mL, 5.84 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as a gummy white solid in a quantitative yield and was used without further purification: ES-MS (m/z) 158 [M+H]+.

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature overnight
  3. customThe solvent was then removed under reduced pressure
  4. customthe product was isolated as a gummy white solid in a quantitative yield
  5. customwas used without further purification

출처 및 근거

ORD 기록
ord-e124249dffc94b568ce894a982876f22
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208513B2

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