Hydrazine → Glycine, N,N-diethyl-, hydrazide

HRID 1272976

반응식

HRID 1272976 반응식
[CH2:1]([N:3]([CH2:9][CH3:10])[CH2:4][C:5](OC)=[O:6])[CH3:2].[NH2:11][NH2:12]>C(O)C>[NH2:11][NH:12][C:5](=[O:6])[CH2:4][N:3]([CH2:9][CH3:10])[CH2:1][CH3:2]

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 559451N,N-Diethylglycine Methyl Ester

생성물 1

HCID 200751Glycine, N,N-diethyl-, hydrazide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of methyl 2-(diethylamino)acetate (4.167 mL, 27.55 mmol) in 4 mL of anhydrous ethanol was added anhydrous hydrazine (1.336 mL, 27.55 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as an oil in a quantitative yield and was used without further purification: 1H NMR (CDCl3) δ 8.3 (br s, 1H), 3.83 (br s, 2H), 3.08 (s, 2H), 2.51 (q, 4H), 1.00 (t, 6H); ES-MS (m/z) 146 [M+H]+.

후처리

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature overnight
  3. customThe solvent was then removed under reduced pressure
  4. customthe product was isolated as an oil in a quantitative yield
  5. customwas used without further purification

출처 및 근거

ORD 기록
ord-daf6fe1796a84888af5f076f3f492ef8
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07208513B2

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