HCID 58994249, 화합물 → HCID 58994157, 화합물

HRID 12735노트

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HRID 12735 반응식
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2[CH3:18])[C:9](=[O:19])[NH:8][C:7]1=[O:20]>C1COCC1>[CH3:18][C:17]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:10]1[C:9](=[O:19])[NH:8][C:7](=[O:20])[N:6]([CH2:5][CH2:4][CH:3]=[O:2])[CH:11]=1

참가 물질

3

반응물 1

HCID 58994249HCID 58994249, 화합물

생성물 1

HCID 58994157HCID 58994157, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
40 °C

실험 절차

1-(3,3-Dimethoxy-propyl)-5-(4-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione (Pre112, 100 mg, 0.32 mmol) was dissolved in THF (5 ml) and 1N HClaq (327 μl) was added. The solution was then stirred at 40° C. for 1.5 hours. TEA (45 μl) was added and the solvent was carefully removed in vacuum at room temperature. Residue was freeze dried to give the title compound that was used in the next step without further purification (quantitative yield).

후처리

  1. addition1N HClaq (327 μl) was added
  2. customthe solvent was carefully removed in vacuum at room temperature
  3. customdried

출처 및 근거

ORD 기록
ord-ec7bd10461df43f8b74b205be880fb9b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727988B2

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