Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2,3-Dichloroanisole | HCID 16126 | — |
| 반응물 | 2-Benzofurancarbonyl chloride | HCID 38949 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone | HCID 54547284 | 76.1% |
반응 단계
14 g (0.1 mole) of aluminium chloride are introduced little by little in a solution of 16 g (0.09 mole) of 2,3-dichloro-anisol and 16 g (0.09 mole) of 2-benzofurancarboxylic acid chloride in 200 ml of methylene chloride the mixture is taken up to reflux for 4 hours, then poured on crushed ice (300 g) and concentrated hydrochloric acid (10 ml); the precipitate is filtered off, washed with an aqueous solution of sodium hydroxide (10 N), then with water and dried. 22 g of 2-benzofuryl (2,3-dichloro-4-methoxy-phenyl) ketone are obtained. Melting point 148° C. after crystallization from ethylacetate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04255585 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-45d108e2ff734fdfbc1b4d48fc16e452 |
| 출처 메모 | uspto-grants-1981_03 |