Methanol → 2-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one

HRID 1274072

반응식

HRID 1274072 반응식
[CH3:1][C:2]1[C:3]([N+:11]([O-])=O)=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([NH2:7])=[O:6].[CH3:14][OH:15]>[Pd]>[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]2[C:3]=1[N:11]=[C:1]([C:2]1[CH:3]=[CH:4][C:14]([OH:15])=[CH:9][CH:10]=1)[NH:7][C:5]2=[O:6]

참가 물질

4

반응물 2

HCID 887MethanolHCID 32713713-Methyl-2-nitrobenzamide

생성물 1

HCID 1354713542-(4-Hydroxy-phenyl)-8-methyl-3H-quinazolin-4-one

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

3-Methyl-2-nitrobenzamide (1.20 g, 6.7 mmol) was dissolved in methanol and 10% activated palladium on carbon catalyst (150 mg) was added. The reaction vessel was placed under an atmosphere of hydrogen, at ambient temperature and pressure, until no further hydrogen absorption was observed. The catalyst was removed by filtration of the reaction mixture through a pad of Celite™, which was pre-washed with methanol (150 ml). The solvent was removed under vacuum to give the required product in good yield. The product was used for subsequent reactions without further purification. Yield (0.97 g, 6.4 mmol, 97%), m.p. 145-147° C.

후처리

  1. additionwas added
  2. customwas placed under an atmosphere of hydrogen, at ambient temperature
  3. custompressure, until no further hydrogen absorption
  4. customThe catalyst was removed by filtration of the reaction mixture through a pad of Celite™, which
  5. washwas pre-washed with methanol (150 ml)
  6. customThe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-f70cb71b2d6e4d27b26650ce00641735
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06156739

연결된 노트

불러오는 중…