Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Carbonyldiimidazole → HCID 20293650, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 2-Aminomethyl-1-ethylpyrrolidine | HCID 117295 | — |
| 반응물 | 7-Ethylsulfonyl-1,4-benzodioxane-5-carboxylic acid | HCID 20544758 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 20293650 | HCID 20293650 | 76.7% |
반응 단계
13 g of 7-ethylsulfonyl-1,4-benzodioxane-5-carboxylic acid, 300 ml of tetrahydrofuran and 13 g of carbonyldiimidazole were introduced into a balloon flask provided with an agitator, a thermometer and a condenser. The mixture was agitated at ambient temperature and then 9.5 g of 1-ethyl-2-aminomethylpyrrolidine was added. Agitation was maintained at ambient temperature and then the solvent was evaporated under vacuum. The crystals produced were washed with water and then dried. 14 g of N-(1-ethyl-2-pyrrolidylmethyl)-7-ethylsulfonyl-1,4-benzodioxane-5-carboxamide was produced (M.P.: 118°-119° C.; yield: 73.8%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04255580 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-9a5a643d93394373bc0f9a3d0e24ae3c |
| 출처 메모 | uspto-grants-1981_03 |