Methanol → 3,5,6-Trifluoro-4-methylpyridin-2-amine
반응식
CO.C([NH:10][C:11]1[C:16]([F:17])=[C:15]([CH3:18])[C:14]([F:19])=[C:13]([F:20])[N:12]=1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[NH2:10][C:11]1[C:16]([F:17])=[C:15]([CH3:18])[C:14]([F:19])=[C:13]([F:20])[N:12]=1참가 물질
5
실험 절차
To 4 ml of methanol were added all amount of the crude 2-benzylamino-3,5,6-trifluoro-4-methylpyridine as described above together with 0.18 g of 10% palladium on carbon and 2 ml of acetic acid, and the mixture was hydrogenated at 50° C. for one day. The catalyst was separated by filtration, and the solvent and the like were distilled off under reduced pressure to obtain 1.35 g of the title compound as a colorless solid.
후처리
- customThe catalyst was separated by filtration
- distillationthe solvent and the like were distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-83ca085e6599421191d4f101f562f1a4
- 출처 데이터셋
- uspto-grants-2000_12
- 특허 번호
- US06156903
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