2-Chloro-10H-pyridazino(6,1-b)quinazolin-10-one → HCID 20284571, 화합물
반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2.[CH3:17][O-:18].[Na+]>CO>[CH3:17][O:18][C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2참가 물질
4
실험 절차
2-Chloro-10H-pyridazino[3,2-b]quinazolin-10-one (2.3 g) and sodium methoxide (1.1 g) in 100 ml of methanol was heated at 60° C. for 5 hours. After completion of the reaction, the solvent was removed by distillation, followed by addition of an aqueous solution of acetic acid. The precipitates were collected by filtration and recrystallized from methanol to give 1.6 g of 2-methoxy-10H-pyridazino[3,2-b]-quinazolin-10-one (Compound No. 1). M.P., 222.5°-223.0° C.
후처리
- customAfter completion of the reaction
- customthe solvent was removed by distillation
- additionfollowed by addition of an aqueous solution of acetic acid
- filtrationThe precipitates were collected by filtration
- customrecrystallized from methanol
출처 및 근거
- ORD 기록
- ord-f2a92ad9e11149c287c2f3e9fce12779
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04256483
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