Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → L-Tryptophan
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Diethyl formamido[(1H-indol-3-yl)methyl]propanedioate | HCID 292164 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | L-Tryptophan | HCID 6305 | 100.8% |
반응 단계
A mixture of 40 g (0.12 mol) of the compound of Example 6 and 24.0 g (0.60 mol) of sodium hydroxide in 240 ml. of water was heated at reflux for 18 hours. 48 ml of glacial acetic acid was added to the solution and heating was continued for an additional 8 hours. The suspension was allowed to stand at 0° overnight and the white precipitate was collected, washed with icecold water and dried to yield 24.7 g (100%) of crude product. Recrystallization from 80% aqueous acetic acid afforded, after drying at 100°/0.05 mmHg, 21.2 g (86%) of white crystals, m.p. 292° (dec.) (lit. m.p. 293°) which was identical with an authentic sample.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04256641 |
| 출처 데이터셋 | uspto-grants-1981_03 |
| ORD ID | ord-b928bad099654bda9854fa73bcb5144e |
| 출처 메모 | uspto-grants-1981_03 |