p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
반응식
[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].C1(C)C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:20]([F:21])=[C:19]([F:22])[CH:18]=[C:17]([F:23])[C:3]=1[C:4]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5]참가 물질
4
실험 절차
To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).
후처리
- temperaturethe mixture is refluxed for 2.5 hours
- temperatureAfter cooling
- extractionthe resultant is extracted with diethyl ether
- dry with materialthe extract is dried over magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-2da68ab0871c4a05aa3d4f9224f8df1c
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05723648
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