1-Naphthoic acid → 5-Bromonaphthalene-1-carboxylic acid

HRID 1275002

반응식

HRID 1275002 반응식
[C:1]1([C:11]([OH:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Br:14]Br>C(O)(=O)C>[Br:14][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:5]=1[CH:4]=[CH:3][CH:2]=[C:1]2[C:11]([OH:13])=[O:12]

참가 물질

4

반응물 2

HCID 68471-Naphthoic acidHCID 24408Bromine

생성물 1

HCID 6976055-Bromonaphthalene-1-carboxylic acid수율 76.6%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

To a stirred suspension of 1-naphthoic acid (90 g, 0.52 mol) in glacial acetic acid at 100° C. was added bromine (84 g, 0.52 mol). The reaction was stirred at this temperature for 1.5 hours and then allowed to cool overnight. The resulting slurry was diluted with glacial acetic acid, the solid collected by filtration, resuspended in water, filtered and dried in vacuo to give 5-bromo-1-napthoic acid (100 g). The acid was converted to the title compound using a similar procedure to Description 3 (68%).

후처리

  1. temperatureto cool overnight
  2. filtrationthe solid collected by filtration
  3. filtrationfiltered
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-e9e92af35b7048118ae5132f21b707db
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06159979

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