5-Bromonaphthalene-1-carboxylic acid → 5-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]naphth-1-yl Carboxamide

HRID 1275011

반응식

HRID 1275011 반응식
[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]([OH:14])=O.[CH3:15][O:16][C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][C:18]=1[N:24]1[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]1>>[Br:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]([NH:21][C:20]1[CH:22]=[CH:23][C:17]([O:16][CH3:15])=[C:18]([N:24]2[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]2)[CH:19]=1)=[O:14]

참가 물질

3

반응물 2

HCID 6976055-Bromonaphthalene-1-carboxylic acidHCID 103311014-Methoxy-3-(4-methylpiperazin-1-yl)aniline

생성물 1

HCID 221188965-Bromo-N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]naphth-1-yl Carboxamide

실험 절차

The title compound was prepared from 5-bromo-1-naphthoic acid (J. Chem. Soc., 1950, 991) and 4-methoxy-3-(4-methylpiperazin-1-yl)aniline (EP0533268A1) using a similar procedure to Example 1.

출처 및 근거

ORD 기록
ord-67f3c750e9df4b7b970699adb11e204b
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06159979

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