1H-Indole, 6-methyl- → Alpha-nitro-6-methyl-3-indoleacrylic acid methylester

HRID 127506

반응식

HRID 127506 반응식
[CH3:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:11][O:12][C:13](=[O:22])[C:14]([N+:19]([O-:21])=[O:20])=[CH:15]OCC>>[CH3:11][O:12][C:13](=[O:22])[C:14]([N+:19]([O-:21])=[O:20])=[CH:15][C:6]1[C:5]2[C:9](=[CH:10][C:2]([CH3:1])=[CH:3][CH:4]=2)[NH:8][CH:7]=1

참가 물질

3

반응물 2

HCID 1379281H-Indole, 6-methyl-HCID 53395203alpha-Nitro-beta-ethoxyacrylic acid methylester

생성물 1

HCID 54365062Alpha-nitro-6-methyl-3-indoleacrylic acid methylester

실험 절차

A mixture of 32.5 g (0.25 mol) of 6-methylindole and 52.5 g (0.30 mol) of α-nitro-β-ethoxyacrylic acid methylester was let stand in a large crystallization dish at room temperature for 20 hours. The brown-orange solid was triturated with ether-hexane 1:1, the crystalline material collected by filtration, washed with ether and dried to afford 44.5 g. (69%) of product as orange crystals, m.p. 167°-169°.

후처리

  1. customat room temperature
  2. customfor 20 hours
  3. customThe brown-orange solid was triturated with ether-hexane 1:1
  4. filtrationthe crystalline material collected by filtration
  5. washwashed with ether
  6. customdried
  7. customto afford 44.5 g

출처 및 근거

ORD 기록
ord-e1d95fc4561949359c3640c74721b0b7
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04256641

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