Bromine → 6-Amino-7-bromobenzothiazole
반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]2[N:6]=[CH:7][S:8][C:4]=2[CH:3]=1.[Br:11]Br.CCOC(C)=O.CCCCCC>CC(O)=O.CCOC(C)=O>[Br:11][C:3]1[C:4]2[S:8][CH:7]=[N:6][C:5]=2[CH:9]=[CH:10][C:2]=1[NH2:1]참가 물질
6
반응 조건
- 온도
- 25 °C
실험 절차
To a solution of 6-aminobenzothiazole (16 g, 107 mmol) in 100 mL of AcOH was added Br2 (2.0 mL, 43 mmol) dropwise and the resulting reaction mixture was stirred for 1 h at 25° C. Reaction mixture was concentrated in vacuo, yielding a yellow solid which was dissolved in EtOAc and washed with aq. NaHCO3. Organic layer was dried over Na2SO4 and concentrated in vacuo, yielding an oil which was subjected to column chromatography (10-50% EtOAc/n-Hexane) to obtain 7.8 g (34 mmol, 80 ) of the desired product.
후처리
- customthe resulting reaction mixture
- customReaction mixture
- concentrationwas concentrated in vacuo
- customyielding a yellow solid which
- washwashed with aq. NaHCO3
- dry with materialOrganic layer was dried over Na2SO4
- concentrationconcentrated in vacuo
- customyielding an oil which
출처 및 근거
- ORD 기록
- ord-05330d173d92468789e937fc7c3aa8db
- 출처 데이터셋
- uspto-grants-2000_12
- 특허 번호
- US06159998
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