HCID 20284765, 화합물 → 4-Formyl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indole

HRID 127514

반응식

HRID 127514 반응식
[OH:1][CH2:2][C:3]#[C:4][CH2:5][S:6][C:7]1[NH:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2>N1C=CC=CC=1>[CH:2]([CH:3]1[C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][C:7]=2[S:6][CH2:5][CH2:4]1)=[O:1]

참가 물질

3

반응물 1

HCID 20284765HCID 20284765, 화합물

생성물 1

HCID 147356294-Formyl-2,3,4,9-tetrahydrothiopyrano[2,3-b]indole수율 67.8%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of the product of the above (1) (12.0 g) in pyridine (120 ml) is heated at 100° C. for 2 hours and evaporated to remove the pyridine. The residue is dissolved in ether (300 ml), washed with water, 2 N hydrochloric acid and a saturated saline solution, dried and evaporated to remove the solvent. The residue (11.0 g) is chromatographed on silica gel (50 g) and eluted with benzene. The eluate is evaporated to give the title compound as an oil (8.14 g). The oil is gradually solidified in a refrigerator.

후처리

  1. customevaporated
  2. customto remove the pyridine
  3. dissolutionThe residue is dissolved in ether (300 ml)
  4. washwashed with water, 2 N hydrochloric acid
  5. customa saturated saline solution, dried
  6. customevaporated
  7. customto remove the solvent
  8. customThe residue (11.0 g) is chromatographed on silica gel (50 g)
  9. washeluted with benzene
  10. customThe eluate is evaporated

출처 및 근거

ORD 기록
ord-92bc557fabfd4287adee9bad8db427cd
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04256640

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