p-Toluenesulfonic acid → 1,2-Difluoro-4-(prop-1-en-2-yl)benzene

HRID 1275210노트

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HRID 1275210 반응식
[F:1][C:2]1[CH:3]=[C:4]([C:9](O)([CH3:11])[CH3:10])[CH:5]=[CH:6][C:7]=1[F:8].C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[F:8][C:7]1[CH:6]=[CH:5][C:4]([C:9]([CH3:11])=[CH2:10])=[CH:3][C:2]=1[F:1]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 108210712-(3,4-Difluorophenyl)propan-2-ol

생성물 1

HCID 155252121,2-Difluoro-4-(prop-1-en-2-yl)benzene

시약·촉매·용매 1

HCID 241Benzene용매

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온도
60 °C

실험 절차

To a solution of 2-(3,4-difluorophenyl)propan-2-ol (1.0 g, 5.8 mmol) in 40 mL benzene was added 0.1 g of p-toluenesulfonic acid and the solution was heated to 60° C. TLC analysis showed disappearance of the starting material. After cooling, the solution was extracted with EtOAc, washed with saturated NaHCO3, dried over Na2SO4, filtered and the solvent was removed in vacuo. 1,2-difluoro-4-isopropenyl-benzene was obtained as a yellow oil (0.82 g, 92% yield).

후처리

  1. temperatureAfter cooling
  2. extractionthe solution was extracted with EtOAc
  3. washwashed with saturated NaHCO3
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-78a88cf5289144cfa62a1ab57ec6aa43
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06159990

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