Sodium hydrosulfide hydrate → Sodium 2-hydroxy-3-sulfanylpropane-1-sulfonate
반응식
O.Cl[CH2:3][CH:4]([OH:10])[CH2:5][S:6]([O-:9])(=[O:8])=[O:7].[Na+:11].O.[SH-:13].[Na+]>CN(C=O)C>[SH:13][CH2:3][CH:4]([OH:10])[CH2:5][S:6]([O-:9])(=[O:8])=[O:7].[Na+:11]참가 물질
4
실험 절차
To sodium 3-chloro-2-hydroxypropanesulfonate hydrate (2.0 g), sodium hydrosulfide hydrate (0.42 g) was added in 10 mL DMF. The mixture was refluxed overnight. When the reaction mixture was cooled down, white solid was isolated, rinsed with ether and acetone to obtain 1.9 g crude sodium 3-mercapto-2-hydroxypropane sulfonate. The crude product was dissolved in water and preferentially precipitated the desired product by adding acetone. The precipitated product was then filtered and dried under vacuum to get 1.04 g of the title compound.
후처리
- temperatureThe mixture was refluxed overnight
- temperatureWhen the reaction mixture was cooled down
- customwhite solid was isolated
- washrinsed with ether and acetone
출처 및 근거
- ORD 기록
- ord-dba88060dfeb4f4c8d98aa631c8a672c
- 출처 데이터셋
- uspto-grants-2000_12
- 특허 번호
- US06160167
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