3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole → HCID 11312687, 화합물

HRID 1275714노트

반응식

HRID 1275714 반응식
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:18][C:19]([CH2:22][OH:23])=[CH:20][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(Cl)(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[O:18][C:19]([CH:22]=[O:23])=[CH:20][CH:21]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 57123-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole

생성물 1

HCID 11312687HCID 11312687, 화합물

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 5943Carbon Tetrachloride용매

실험 절차

7.7 g (25.3 mmol) of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole and 11 g (126.5 mmol) of activated manganese(IV) oxide in 200 ml of dry carbon tetrachloride were stirred under reflux for 4.5 h. For work-up, the mixture was filtered off with suction and the filtrate was washed with water, dried and concentrated using a rotary evaporator. The crude product was recrystallized from isopropanol. This gave 4.8 g (63%) of the title compound. m.p.: 108° C.

후처리

  1. temperatureunder reflux for 4.5 h
  2. filtrationFor work-up, the mixture was filtered off with suction
  3. washthe filtrate was washed with water
  4. customdried
  5. concentrationconcentrated
  6. customa rotary evaporator
  7. customThe crude product was recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-e9b5cab4f8fe4c76978e9b6f07b7284d
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06162819

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