Trifluoroacetic acid → HCID 138962835, 화합물

반응식

[C:1]([NH:9][C:10](=[N:13]C(OCCCC)=O)[S:11][CH3:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(OC)C=CC=CC=1.C(O)(C(F)(F)F)=O>>[C:1]([NH:9][C:10](=[NH:13])[S:11][CH3:12])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 6422Trifluoroacetic acid

HCID 7519Anisole

HCID 57037267N-Benzoyl-N'-butyloxycarbonyl-S-methylisothiourea

생성물 1

HCID 138962835HCID 138962835, 화합물수율 128.7%

실험 절차

To a mixture of 78b (160 mg, 0.54 mmol) and anisole (0.1 mL) was added TFA (1.0 mL). The resulting mixture was stirred for 30 min at room temperature, evaporated to dryness and put on vacuum line for 2 hours, and triturated with anhydrous Et2O to give 135 mg of 79b as a semi-solid. This crude product was used directly in the next step without further purification. 1HNMR (300 MHz, CD3OD): δ2.74 (3H, m); 7.55 (2H, t, J=7.8 Hz); 7.69 (1H, t, J=7.5 Hz); 8.02 (2H, d, J=7.5 Hz) ppm. IR (NaCl, film): 3226, 2936, 1695, 1680, 1540, 1188 cm-1.