Aniline → Prinomide

HRID 127587

반응식

HRID 127587 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:16])[CH:8]([C:11]([O:13]CC)=O)[C:9]#[N:10].[NH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C1(C)C(C)=CC=CC=1>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=[O:16])[CH:8]([C:11](=[O:13])[NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]#[N:10]

참가 물질

4

반응물 2

HCID 6115AnilineHCID 202854131-Methyl-beta-oxo-alpha-ethoxycarbonyl-2-pyrrolepropionitrile

생성물 1

HCID 60352Prinomide

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

The mixture of 1.1 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 1.1 g of aniline and 60 ml of xylene, is refluxed for 41/2 hours. After standing and cooling to room temperature overnight, the solution is filtered, evaporated and the residue recrystallized from methanol, to yield the 1-methyl-β-oxo-α-phenylcarbamoyl-2-pyrrolpropionitrile melting at 173°-174°; it is identical with that obtained according to Example 1.

후처리

  1. temperatureis refluxed for 41/2 hours
  2. filtrationthe solution is filtered
  3. customevaporated
  4. customthe residue recrystallized from methanol

출처 및 근거

ORD 기록
ord-92b9856cc49644c097908df62f3abed0
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04256759

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