2-[2,4-Dimethylphenyl]-4,5-dihydro-4,4-dimethyloxazole → 4,5-Dihydro-4,4-dimethyl-2-[4-methyl-2-[2-[2,3-dimethylphenyl]ethyl]phenyl]oxazole

HRID 1275905

반응식

HRID 1275905 반응식
[CH2:1]([Li])[CH2:2][CH2:3][CH3:4].[CH3:6][C:7]1([CH3:20])[CH2:11][O:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=2[CH3:19])=[N:8]1>O1CCCC1>[CH3:6][C:7]1([CH3:20])[CH2:11][O:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=2[CH2:19][CH2:1][C:2]2[CH:14]=[CH:13][CH:12]=[C:17]([CH3:16])[C:3]=2[CH3:4])=[N:8]1

참가 물질

4

반응물 2

HCID 221172732-[2,4-Dimethylphenyl]-4,5-dihydro-4,4-dimethyloxazoleHCID 178418339Butyllithium

생성물 1

HCID 221172044,5-Dihydro-4,4-dimethyl-2-[4-methyl-2-[2-[2,3-dimethylphenyl]ethyl]phenyl]oxazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

n-Butyllithium (6.9 ml of a 2.5M soln in hexanes) was added dropwise to the product of example 21 step (i) (3.51 g) in tetrahydrofuran (60 ml) at -78° C. After 2 hours the product from step (i) (3.45 g) was added. After 1 hour the solution was left to warm to room temperature. The solution was quenched with water and extracted with ethyl acetate. The organic solution was dried (MgSO4) and evaporated under reduced pressure. Yield 1.83 g.

후처리

  1. customThe solution was quenched with water
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic solution was dried (MgSO4)
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-91762cdd6cfb4b918869ccc2090b8faa
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06162808

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