5-Bromomethyl-2-furancarboxylic acid ethyl ester → (+/-)-5-[[3,4-Dihydro-5-{2-methyl-8-[l-methylethyl]-5H-dibenzo[a,d]cyclohepten-5-yl}-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester

HRID 1275918

반응식

HRID 1275918 반응식
[CH3:1][C:2]1[CH:27]=[CH:26][C:5]2[CH:6]([C:18]3[C:19](=[O:25])[NH:20][C:21](=[O:24])[NH:22][CH:23]=3)[C:7]3[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][C:8]=3[CH:9]=[CH:10][C:4]=2[CH:3]=1.[CH2:28]([O:30][C:31]([C:33]1[O:34][C:35]([CH2:38]Br)=[CH:36][CH:37]=1)=[O:32])[CH3:29]>>[CH3:1][C:2]1[CH:27]=[CH:26][C:5]2[CH:6]([C:18]3[C:19](=[O:25])[NH:20][C:21](=[O:24])[N:22]([CH2:38][C:35]4[O:34][C:33]([C:31]([O:30][CH2:28][CH3:29])=[O:32])=[CH:37][CH:36]=4)[CH:23]=3)[C:7]3[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][C:8]=3[CH:9]=[CH:10][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 137895295-Bromomethyl-2-furancarboxylic acid ethyl esterHCID 22117255(+/-)-5-[2-Methyl-8-[1-methylethyl]-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 131722233(+/-)-5-[[3,4-Dihydro-5-{2-methyl-8-[l-methylethyl]-5H-dibenzo[a,d]cyclohepten-5-yl}-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester

실험 절차

The subtitle compound was prepared from the product of step (vi) (1 g) and 5-bromomethyl-2-furancarboxylic acid ethyl ester (J. Chem. Soc. Perkin Trans. 1, 1981, 1125, Bull. Chem. Soc. Jpn. 1987, 60, 1807)(0.65 g) according to the method of example 1 step (iv). Purification was by chromatography eluting with 20% ethyl acetate in toluene. Yield 0.375 g.

후처리

  1. customPurification
  2. washeluting with 20% ethyl acetate in toluene

출처 및 근거

ORD 기록
ord-e2b6780fc86a4a43beb91476d39bcc0d
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06162808

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