1H-Pyrrole-2,4-dicarboxylic acid, 1,3,5-trimethyl-, diethyl ester → 5-Ethoxycarbonyl-1,2,4-trimethylpyrrole-3-carboxylic acid

HRID 127601노트

반응식

HRID 127601 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:18])[C:8]([CH3:17])=[C:9]([C:12]([O:14]CC)=[O:13])[C:10]=1[CH3:11])=[O:5])[CH3:2]>S(=O)(=O)(O)O>[CH3:18][N:7]1[C:8]([CH3:17])=[C:9]([C:12]([OH:14])=[O:13])[C:10]([CH3:11])=[C:6]1[C:4]([O:3][CH2:1][CH3:2])=[O:5]

참가 물질

3

반응물 1

HCID 2267561H-Pyrrole-2,4-dicarboxylic acid, 1,3,5-trimethyl-, diethyl ester

생성물 1

HCID 3437565-Ethoxycarbonyl-1,2,4-trimethylpyrrole-3-carboxylic acid

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

The starting material is prepared as follows: The mixture of 11.9 g of 1,3,5-trimethylpyrrole-2,4-dicarboxylic acid diethyl ester and 50 ml of concentrated sulfuric acid is heated on the steam cone for 1 hour. The resulting solution is poured on to ice, the precipitate collected and washed with water. It it taken up in aqueous sodium carbonate, the solution filtered and the filtrate acidified with 5 N hydrochloric acid. The precipitate formed is collected, washed with water, dried and recrystallized from ethanol, to yield the 1,3,5-trimethyl-2-carbethoxypyrrole-4-carboxylic acid melting at 197°-198° with decomposition.

후처리

  1. customThe starting material is prepared
  2. temperatureis heated on the steam cone for 1 hour
  3. additionThe resulting solution is poured on to ice
  4. customthe precipitate collected
  5. washwashed with water
  6. filtrationthe solution filtered
  7. customThe precipitate formed
  8. customis collected
  9. washwashed with water
  10. customdried
  11. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-5227082544d54f6cb71df3bc0431d122
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04256759

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