1-Benzyl-4-phenyl-3-pyrrolidinemethanol → (4-Phenylpyrrolidin-3-yl)methanol

반응식

C([N:8]1[CH2:12][CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:10]([CH2:19][OH:20])[CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2]>[OH:20][CH2:19][CH:10]1[CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][NH:8][CH2:9]1

참가 물질

실험 절차

A mixture of 302 mg (1.1 mmol) of 1-benzyl-3-(SR)-hydroxymethyl-4-(SR)-phenylpyrrolidine (from Example 1, Step B) and 154 mg of 20% Pd(OH)2/C was hydrogenated at 40 psi on a Paar apparatus for 1 h. The catalyst was filtered and the filtrate was concentrated in vacuo to afford 196 mg (98%) of the title compound as an oil. 1H NMR (500 MHz, CDCl3): δ2.53-2.57 (m, 2H), 3.06-3.60 (6H), 7.24-7.35 (5H). Mass Spectrum (NH3-CI): m/z 178 (M+1).

후처리

filtrationThe catalyst was filtered
concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록: ord-9bf2a641b70a47dc8deafdc03379aca3
출처 데이터셋: uspto-grants-2000_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06166037

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참가 물질

반응물 1

HCID 219127561-Benzyl-4-phenyl-3-pyrrolidinemethanol

생성물 1

HCID 13316928(4-Phenylpyrrolidin-3-yl)methanol수율 100.5%

시약·촉매·용매 1

HCID 9942167Palladium hydroxide촉매

실험 절차

후처리

filtrationThe catalyst was filtered
concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록: ord-9bf2a641b70a47dc8deafdc03379aca3
출처 데이터셋: uspto-grants-2000_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06166037

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불러오는 중…