Acetone → 3-(Methylsulfonyl)benzenesulfonamide

HRID 1276524노트

반응식

HRID 1276524 반응식
CS[C:3]1[CH:4]=[C:5]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:6]=[CH:7][CH:8]=1.OO[S:15]([O-:17])=[O:16].[K+].[CH3:19]C(C)=O>>[CH3:19][S:15]([C:7]1[CH:6]=[C:5]([S:9]([NH2:12])(=[O:11])=[O:10])[CH:4]=[CH:3][CH:8]=1)(=[O:17])=[O:16]

참가 물질

4

반응물 3

HCID 180AcetoneHCID 18461638HCID 18461638, 화합물HCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 136682473-(Methylsulfonyl)benzenesulfonamide

실험 절차

To a solution of 3-methylsulfanylbenzenesulfonamide (500 mg, 2.5 mmol) in acetone was added an aqueous solution of OXONE (3.2 grams, 5 mmol). The mixture was stirred at room temperature for 12 hours. The reaction was evaporated to dryness in vacuo. The residue was triturated with acetone and filtered. The filtrated was evaporated to give 460 mg of the titled compound.

후처리

  1. customThe reaction was evaporated to dryness in vacuo
  2. customThe residue was triturated with acetone
  3. filtrationfiltered
  4. customThe filtrated was evaporated

출처 및 근거

ORD 기록
ord-e03dc7965cad4f6bac233f4eed9e81e8
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06166064

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