Pyridine → L-Tryptophanamide

HRID 1276591노트

반응식

HRID 1276591 반응식
Cl.CO[C:4](=[O:17])[C@H:5]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1)[NH2:6].[N:18]1C=CC=CC=1>ClCCl>[NH2:6][C@H:5]([C:4]([NH2:18])=[O:17])[CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[NH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 1049PyridineHCID 2734891Methyl tryptophanate hydrochloride

생성물 1

HCID 439356L-Tryptophanamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of the active ester VIII (0.035 g, 0.06 mmol), L-tryptophan methyl ester hydrochloride (0.049 g, 0.19 mmol) and pyridine (0.015 g, 0.19 mmol) in dichloromethane (20 ml) was stirred overnight. The solvent was removed under reduced pressure and the residue purified by column chromatography (ethyl acetate elution) to yield the trytophan amide as a dark red crystalline solid.

후처리

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified by column chromatography (ethyl acetate elution)

출처 및 근거

ORD 기록
ord-1b4fd1c1137a43baa4c47018ac7cf7d7
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06166202

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