5-Fluorouracil → Tegafur
반응식
[F:1][C:2]1[C:3](=[O:9])[NH:4][C:5](=[O:8])[NH:6][CH:7]=1.[O:10]1[CH:14]=[CH:13][CH2:12][CH2:11]1>O1CCOCC1>[O:10]1[CH2:14][CH2:13][CH2:12][CH:11]1[N:6]1[CH:7]=[C:2]([F:1])[C:3](=[O:9])[NH:4][C:5]1=[O:8]참가 물질
4
실험 절차
Into 30 ml of dioxane were suspended 1.3 g of 5-fluorouracil. To this suspension were added 1.4 g of 2,3-dihydrofuran and the mixture was reacted in an autoclave for 5 hours at 170° C. After completion of the reaction, the reaction liquid was treated in the same manner as described in Example 1 whereby 0.40 g of the starting 5-fluorouracil was recovered as a substance insoluble in chloroform and 1.10 g of 1-(2-tetrahydrofuryl)-5-fluorouracil was obtained. The yield of the end product was 79.5% based on the consumed 5-fluorouracil.
후처리
- customthe mixture was reacted in an autoclave for 5 hours at 170° C
- customAfter completion of the reaction
- customthe reaction liquid
- additionwas treated in the same manner
- customwas recovered as a substance insoluble in chloroform
출처 및 근거
- ORD 기록
- ord-d1ac9c22a9bc4922b59d895cd480e6ec
- 출처 데이터셋
- uspto-grants-1981_03
- 특허 번호
- US04256885
반응 노트
불러오는 중…