Toluene → Methyl 4-(pyridin-2-YL)benzoate

HRID 1277005

반응식

HRID 1277005 반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([C:10]#[N:11])=[CH:6][CH:5]=1.C#C.[C:15]1(C)[CH:20]=CC=[CH:17][CH:16]=1>[CH-]1C=CC=C1.[CH-]1C=CC=C1.[Co+2]>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:17]=[CH:16][CH:15]=[CH:20][N:11]=2)=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 1140Toluene2회HCID 6326AcetyleneHCID 70791Methyl 4-cyanobenzoate

생성물 1

HCID 3358924Methyl 4-(pyridin-2-YL)benzoate

시약·촉매·용매 1

HCID 92884Cobaltocene촉매

반응 조건

온도
80 °C

실험 절차

24.0 g (150 mmol) of 4-cyanobenzoic acid methyl ester (Fluka, Buchs, Switzerland) in 150 ml of toluene are placed under an acetylene atmosphere in an autoclave and 0.30 g (1.6 mmol) of cobaltocene (=dicyclopentadienylcobalt; Aldrich, Milwaukee, USA) is added. The mixture is then subjected to an acetylene pressure of 15 atm, heated at 1 80° C. and stirred for 12 hours. After cooling and release of the pressure, 9.5 g of active carbon are added to the black suspension; the mixture is diluted with 250 ml of toluene, stirred for 30 min, filtered and concentrated by evaporation. Crystallisation from warm ether by the addition of hexane yields the title compound: m.p. 96° C.; TLC (hexane/ethyl acetate 4:1): Rf =0.37; FAB MS (M+H)+ =214. Further product can be obtained from the mother liquor by column chromatography (SiO2, hexane/ethyl acetate 19:1-4:1).

후처리

  1. additionis added
  2. temperatureAfter cooling
  3. additionrelease of the pressure, 9.5 g of active carbon are added to the black suspension
  4. stirringstirred for 30 min
  5. filtrationfiltered
  6. concentrationconcentrated by evaporation
  7. customCrystallisation
  8. temperaturefrom warm ether
  9. additionby the addition of hexane

출처 및 근거

ORD 기록
ord-82c33becb60740b5a2cf6fd5af567601
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06166004

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